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3109 (v.3) Pharmaceutical Chemistry 320
Area: | School of Pharmacy |
Credits: | 25.0 |
Contact Hours: | 3.5 |
Lecture: | 2 x 1 Hours Weekly |
Practical: | 16 x 3 Hours Yearly |
Prerequisite(s): | 12936 (v.2) Pharmaceutical Chemistry 200 or any previous version
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Syllabus: | Approaches to the discovery of drugs. Quantitative structure-activity relationships. Impurity profiles. Mechanisms by which drugs degrade. Introduction to nuclear magnetic resonance spectroscopy and mass spectrometry. Prodrugs. Medicinal chemistry of selected drug groups. Analysis of drugs in therapeutic formulations and biological fluids. General principles of toxicology. Concepts of quality assurance. |
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Unit Outcomes: | On successful completion of this unit students will have - Developed an understanding of the relationship between chemical structure and physico-chemical parameters of drug molecules and their biological activity. Developed an appreciation of the relationship between structure and chemical stability. Demonstrated a basic understanding of certain advanced analytical techniques. Developed a knowledge of the medicinal chemistry of certain drug groups. Demonstrated an understanding of the application of analytical techniques to the analysis of drug related compounds in medicaments and biological fluids. Demonstrated an understanding of the general principles of toxicology, the causes of toxicological manifestations and the scope and limitation of assessment procedures. |
Texts and references listed below are for your information only and current as of September 30, 2003. Some units taught offshore are modified at selected locations. Please check with the unit coordinator for up-to-date information and approved offshore variations to unit information before finalising study and textbook purchases. |
Unit References: | Beckett A.H.and Stenlake J.B., (1988), Parts 1 and 2, Practical Pharmaceutical Chemistry, 4th ed., London, Athlone Press. British Pharmacopoeia, (1998), London, The Stationery Office. Hansch C., Sammes P.G. and Taylor J.B., (Eds.), (1990), ComprehensiveMedicinal Chemistry (6 volumes), Oxford, Pergamon. Morrison R.T. and Boyd R.N., (1992), Organic Chemistry 6th ed., Prentice Hall. Patrick G.L., (2001), An Introduction to Medicinal Chemistry, 2nd ed., Oxford University Press. Wermuth C.G.W., (Ed.), (1996), The Practice of Medicinal Chemistry, Academic Press. |
Unit Texts: | Watson D.G., (1999), Pharmaceutical Analysis, London, Churchill Livingstone. Pharmaceutical Chemistry 320 Coursebook, Curtin University of Technology. |
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Unit Assessment Breakdown: | Accuracy in Selected Exercise and General Performance in Practicals 5%. Open Book Practical Tests 20%. Theory Test (Mid Year) 20%. Final Examination 55%. This is by grade/mark assessment. |
Field of Education: | 60500 Pharmacy (Narrow Grouping) | HECS Band (if applicable): | 2 |
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Extent to which this unit or thesis utilises online information: | Informational | Result Type: | Grade/Mark |
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Availability
| Year | Location | Period | Internal | Area External | Central External | | 2004 | Bentley Campus | Full Year | Y | | |
Area
External | refers to external course/units run by the School or Department, offered online or through Web CT, or offered by research. |
Central
External | refers to external course/units run through the Curtin Bentley-based Distance Education Area |
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