8804 (v.8) Biochemistry 231

Area:

School of Biomedical Science

Credits:

25.0

Contact Hours:

5.0

Lecture:

2 x 1 Hours Weekly

Tutorial:

1 x 0.5 Hours Weekly

Practical:

1 x 2.5 Hours Weekly

Prerequisite(s):

    7077 (v.5) Chemistry 124 or any previous version
    OR
    7231 (v.5) Chemistry 118 or any previous version

Syllabus:

Properties and structure of amino acids, pH, pK and buffers, conformation and dynamics of proteins, protein purification and chromatographic techniques, myoglobin, hemoglobin, connective tissue proteins, enzymes, mechanisms of catalysis, computers and the molecular modelling of proteins, enzyme kinetics and measurement, enzyme inhibition, mechanisms of enzyme action, an overview of protein separation techniques. Overview, concepts and designs of metabolism, carbohydrates, glycogen, glycolysis, citric acid cycle, oxidative phosphorylation, electron transport, and fat metabolism.

Unit Outcomes:

On successful completion of this unit students will have - Understood the language of biochemistry. Recognised and draw simple biologically relevant molecules like sugars, fats and amino acids. Appreciated the structure, function and organisation of manyimportant biological molecules. Recognised significant functional and structural features of macromolecules like proteins, carbohydrates and fats. Demonstrated computer skills to manipulate and explore macromolecular structures. Understood the basic molecular organisation of a cell. Demonstrated an understanding of key metabolic pathways at the molecular level. Provided a balanced understanding of the physical, chemical and biological context in which each biomolecule, reaction or pathway operates. Described the major themes relating regulation, structure and function of molecules. Explained and place in context important biochemical techniques and methods. Integrated their biochemistry knowledge with their other course units. Demonstrated practical expertise associated with the performance of simple laboratory procedures. A basic, and sound, biochemical knowledge base for other studies in life sciences.

Text and references listed above are for your information only and current as of September 30, 2003. Please check with the unit coordinator for up-to-date information.

Unit References:

Berg J.M., Tymoczko, J.L., and Stryer, L. (2002). Biochemistry, 5th ed., NY, WH Freeman and Company. Devlin, T.M. (Ed). (2002). Textbook of Biochemistry with Clinical Correlations, 5th ed., NY, Wiley-Liss. Garret, R.H. and Grisham C.M. (1999). Biochemistry, 2nd ed., NY, Saunders College Publishing. Nelson, D.L. and Cox, M.M. (2000). Lehninger Principles of Biochemistry, 3rd ed., Worth Publishers. Mathews, C.W., Van Holde, K.E., and Ahern, K.G. (2000). Biochemistry, 3rd ed., Benjamin/Cummings Publishing Company. Stryer, L. (1995). Biochemistry, 4th ed., NY, WH Freeman and Company. Voet, D., Voet, J.G. and Pratt, C.W. (1999). Fundamentals of Biochemistry. John Wiley and Sons. Wilson, K. and Walker, J. (eds). (2000). Principles and Techniques of Practical Biochemistry, 5th ed., Cambridge University Press. Zubay, G.L. (1999). Biochemistry, 4th ed., WC Brown Publishers.

Unit Texts:

Nelson, D.L. and Cox, M.M. (2000). Lehninger Principles of Biochemistry, 3rd ed., Worth Publishers.

Unit Assessment Breakdown:

Assignments 50%, Examination 50%. This is by grade/mark assessment.

Year	Location	Period	Internal	Area External	Central External
2004	Bentley Campus	Semester 1	Y