3111 (v.3) Pharmaceutics 320

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Area:	School of Pharmacy
Credits:	50.0
Contact Hours:	4.5
Lecture:	1 x 2.5 Hours Weekly
Laboratory:	1 x 2 Hours Weekly
Prerequisite(s):	12936 (v.2) Pharmaceutical Chemistry 200 or any previous version
Syllabus:	Drug stability - stability indicating assays. Chemical decomposition including hydrolysis, oxidation and photolysis. Effects of pH, solvent, dielectric constant and ionic strength on drug stability. Formulation of polypeptides. Sterilisation - dry heat, moist heat. Other forms of sterilisation. Sterilisation testing. Radiopharmacy. Dissolution and bioavailability. In-vivo determination of bioavailability using plasma and urinary data. Bioequivalence of drug products. Antimicrobial preservatives - incidence of microbial contamination, standards for the microbiological quality of pharmaceuticals. Choice of antimicrobial agent in formulated products. Drug delivery systems, drug targeting.
Unit Outcomes:	On successful completion of this unit students will have developed the ability to apply basic physical, chemical and biological knowledge to the formulation of dosage forms, with consideration of drug availability, stability and site of action. Developedan appreciation of the factors involved in the microbiological contamination of pharmaceuticals and methods for its control and so have a basis for the production of pharmaceuticals of appropriate microbiological quality. Developed the analysis and communication of relevant pharmaceutical data through practical experience in the preparation and evaluation of selected pharmaceutical products and formulation. Developed a critical approach to the literature and to the evaluation of relevant data. Developedan appreciation of the role of bioavailability testing, bioequivalency evaluation and in vitro and in vivo dissolution of dosage forms.
Text and references listed above are for your information only and current as of September 30, 2003. Please check with the unit coordinator for up-to-date information.
Unit References:	The Pharmaceutical Codex, (1994), 12th ed., London, The Pharmaceutical Press. Banker G.S.and Rhodes C.T., (Eds), (2002), Modern Pharmaceutics, 4th ed., Marcel Dekker. Winfield A..J. and Richards R.M.E., (1998), Pharmaceutical Practice, 2nd ed., ChurchillLivingstone. Martin A.N., Physical Pharmacy, 4th ed., Lea Febiger. Wilson C.G.and Washington N., (1999), Physiological Pharmaceutics, Ellis Harwood. Gardener J.F. and Pel M.M., (1998), Introduction to Sterilisation, Disinfection and Infection Control, 3rd ed., Churchill Livingstone. Russell A.D., Hugo W.B. and Ayliffe G.A.J., (1999), Principles and Practice of Disinfection, Preservation and Sterilization, 3rd ed., Blackwell Science.
Unit Texts:	Aulton M., (Ed.), (2002), Pharmaceutics - The Science of Dosage Form Design, 2nd ed., Churchill Livingstone. Australian Pharmaceutical Formulary and Handbook, (2002), 18th ed., Canberra, Pharmaceutical Society of Australia. Florence A.T. and Attwood D.,(1998), Physicochemical Principles of Pharmacy, 3rd Ed, London, MacMillan. Pharmaceutics 320 Practical Book, Curtin University of Technology. Dispensing of Sterile Materials, Curtin University of Technology.
Unit Assessment Breakdown:	Assignment 25%. Mid Year Test (Theory) 20%. Final Theory Examination (3 hr paper) 55%. This is by grade/mark assessment.
Year Location Period Internal Area External Central External 2004 Bentley Campus Full Year Y