302291 (v.3) ChE 379 Special Topics (Biochemical Engineering)

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Area:	Department of Chemical Engineering
Credits:	12.5
Contact Hours:	4.0
Lecture:	1 x 2 Hours Weekly
Tutorial:	2 x 2 Hours Fortnightly
Anti Requisite(s):	304768 (v.2) ChE 579 Special Topics or any previous version
Prerequisite(s):	302240 (v.3) ChE 227 Process Principles or any previous version AND 302252 (v.3) ChE 213 Process Engineering Materials - Make active for 2005 -remove discontinuation date or any previous version AND 302253 (v.3) ChE 327 Process Heat Transfer or any previous version
Syllabus:	Introduction to biology and microbiology (cell structure and micro-organisms). Cell chemistry, amino acids, carbohydrates, fats and lipids, protein structure and functions. Molecular biology, role and structure of RNA and DNA, mutation and genetic engineering. Energetics and metabolism (mechanisms and mathematical modelling).Enzymes and their catalytic activity, kinetic of a single substrate reaction. Enzyme inhibition, denaturation and inactivation. Methods of cell immobilisation. External and internal mass transfer limitations in bioprocesses. Stoichiometry of microbial growth. Unstructured models of microbial growth. Structured models of microbial growth. CSTR for bioprocesses. Week 10 - Enzyme catalysis in a CSTR. Chemostats in series. Plug flow and packed bed bioreactors. Gas-liquid mass transfer in bioreactors. Mass balance for two-phase bioreactors. Evaluation of mass transfer coefficient kLa and power requirements in bioreactors.
Unit Outcomes:	On successful completion of this unit students will have gained familiarity with the basic concepts of biochemical engineering, with one third of the course material devoted to the fundamental concepts of biology (cell and molecular biology, genetic engineering, and metabolism), one third devoted to enzyme kinetics relevant to biochemical processes and one third dedicated to the design of biochemical reactors.
Text and references listed above are for your information only and current as of September 30, 2003. Please check with the unit coordinator for up-to-date information.
Unit References:	Shuler, M. L. and Kargi, F., 2002, Bioprocess Engineering: Basic Concepts, Prentice Hall Inc., New York (2002). Raven, P. H. and Johnson, J. B., 1992, Biology, Third Edition, Mosby Year Book, St. Louis. Yin, J., 1999, 'Bio-informatics - A Chemical Engineering Frontier?' Chemical Engineering Progress, November: pp. 65,74. Bailey, J. E., 1998, 'Mathematical Modelling and Analysis in Biochemical Engineering: Past Accomplishments and Future Opportunities'. Biotechnology Progress, 14,20. Schilling, C. H. etal., 1999, 'Metabolic Pathway Analysis- Basic Concepts and Scientific Applications in the Post-genomic Era' Biotechnology Progress, 15,296, 303.
Unit Texts:	Blanch, H. W. and Clark D. S., 1996, 'Biochemical Engineering', Marcel Dekker Inc. New York.
Unit Assessment Breakdown:	Assignments 20%. Quiz 20%. Final examination 60%. This is by grade/ mark assessment.
Year Location Period Internal Area External Central External 2004 Bentley Campus Semester 1 Y