Online Courses Handbook 2003

3111 (v.3) Pharmaceutics 320

Area:	School of Pharmacy
Contact Hours:	4.5
Credits:	50.0
Lecture:	1 x 2.5 Hours Weekly
Laboratory:	1 x 2 Hours Weekly
Prerequisite(s):	12936 (v.2) Pharmaceutical Chemistry 200 or any previous version
Drug stability - stability indicating assays. Chemical decomposition including hydrolysis, oxidation and photolysis. Effects of pH, solvent, dielectric constant and ionic strength on drug stability. Formulation of polypeptides. Sterilisation - dry heat, moist heat. Other forms of sterilisation. Sterilisation testing. An introduction to radioactivity - Its origins and general character, detection and measurement, units. Radiopharmacy. Dissolution and bioavailability. In-vivo determination of bioavailability using plasma and urinary data. Bioequivalence of drug products. Antimicrobial preservatives - incidence of microbial contamination, standards for the microbiological quality of pharmaceuticals. Choice of antimicrobial agent in formulated products. Evaluation of preservatives and special topics.