302487 (v.1) Cytogenetics 232

Area:

School of Biomedical Science

Credits:

12.5

Contact Hours:

3.0

Lecture:

1 x 1 Hours Weekly

Practical:

1 x 2 Hours Weekly

Prerequisite(s):

    302488 (v.1) Molecular Genetics 231 or any previous version
    OR
    10723 (v.3) Genetics 231 or any previous version

Syllabus:

Methods used to identify and analyse individual cytogenetic alterations. Cytogenetic mechanisms of disease expression. Cytogenetic alterations and relationships to specific clinical expression. Cytogenetic alterations related to development of leukemia.

Unit Outcomes:

On successful completion of this unit students will have demonstrated knowledge of basic cytogenetics laboratory techniques necessary to prepare tissue samples for cytogenetic diagnosis. Appreciated and understood the implications of the most common cytogenetic reports that differ from the normal. Recognised the clinical implications of the most common cytogenetic abnormalities encountered in the population. Arranged a karyotype from a metaphase spread and identified the abnormality. Understood the principles of the cell cycle and how it relates to tissue culture. Developed an understanding of the mechanisms which contribute to cytogenetic alterations and determine the possible gametes from a cytogenetic alteration in a parent.

Text and references listed above are for your information only and current as of September 30, 2003. Please check with the unit coordinator for up-to-date information.

Unit References:

Strachan, T. and Read, A.P. (1999). Human Molecular Genetics, 2nd ed. Barch, M., Knutsen, T. and Spurbeck, J.L. (1997). The AGT Cytogenetics Laboratory Manual, 3rd ed., Philadelphia, Lippincott-Raven Press. Mitelman, F. and Karger Basel, K. (1995). An International system for Human Cytogenetic Nomenclature.

Unit Texts:

Gersen, S,l. and Keagle, M.B.(1999). Principles of Clinical Cytogenetics. New Jersey, Humana Press.

Unit Assessment Breakdown:

Assignments (2) 50%. Examination 50%. This is by grade/mark assessment.

Year	Location	Period	Internal	Area External	Central External
2004	Bentley Campus	Semester 2	Y