11601 (v.3) Gene to Protein 331

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Area:	School of Biomedical Science
Credits:	50.0
Contact Hours:	5.0
Lecture:	1 x 2 Hours Weekly
Practical:	1 x 3 Hours Weekly
Prerequisite(s):	8363 (v.6) Biochemistry 232 or any previous version AND 11600 (v.3) Microbiology 232 or any previous version
Syllabus:	Protein structure, engineering proteins, visualising and exploring three-dimensional structure of proteins, computer-aided molecular modelling of proteins and interaction of hormones with receptors. Enzymes. Bioinformatics, molecular evolutionary aspects of DNA and protein sequences.
Unit Outcomes:	On successful completion of this unit students will have- Become aware of the diversity of nucleotide sequence types, including nongenic DNA, in the human genome and the extent of genomic information available over the internet including sequence databases, genome projects, structure databases. Accessed and retrieved this information by searching databases for similar sequences or structures and to learn how to manipulate sequences in different formats and access information from various computer platforms. Acquired skills in analysing protein and nucleotide sequences of interest by searching for conserved functional motifs, by using multiple sequence alignments, and by building molecular phylogenies. Understood how the principles of the methods used for sequence analysis and their underlying assumptions and hence interpret sequence similarities and be able to make biological inferences leading to further experimental investigation. Resolved problems and questions in applied bioinformatics using appropriate analytical tools.
Text and references listed above are for your information only and current as of September 30, 2003. Please check with the unit coordinator for up-to-date information.
Unit References:	Attwood, TK and D J Parry-Smith, D.J. (1999). Introduction to Bioinformatics. UK, Addison Wesley Longman. Page, R.D.M. and Holmes, E.C. (1998). Molecular Evolution - A Phylogenetic Approach. Oxford, Blackwell Sci. Ltd. Gibas, Cynthia, and Jambeck, P. (2001). Developing Bioinformatics Computer Skills. Seabastopol, O'Reilly and Associates. Gibson, G. and Muse, S.V. (2002). A Primer of Genome Science. Sinauer Boston.
Unit Texts:	Krane, D. E. and Raymer, M.L. (2003). Fundamental Concepts of Bioinformatics. San Fancisco, Benjamin Cummings. Hall, B. G. (2001). Phylogenetic Tree Made Easy - A How-To Manual for Molecular Biologists. Massachusetts, USA, Sinauer and Associates Massachusetts.
Unit Assessment Breakdown:	Practical Assignment portfolio 25%. Assignment 25%. Final Examination 50%. This is by grade/mark assessment.
Year Location Period Internal Area External Central External 2004 Bentley Campus Full Year Y