304890 (v.1) Pharmaceutical Formulation 527

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Area:	School of Pharmacy
Contact Hours:	2.0
Credits:	12.5
Lecture:	1 x 1 Hours Weekly
Workshop:	1 x 1 Hours Weekly
General review of stability. Stability problems associated with intravenous fluids, total parenteral nutrition solutions including emulsion formulations and drug solutions stored in the frozen state. Stability calculations and conversion of basic data for use in practical situations. Influence of formulation on injection site, phlebitis and microbial contamination. Formulation of TPN solutions. Solubility problems associated with pharmaceutical systems such as intravenous fluids. Effect of change of solvent, common-ion effect, salting out, pH. Formulation of specific dosage forms.