11534 (v.2) Pharmacokinetics 224

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Area:	School of Pharmacy
Contact Hours:	2.0
Credits:	12.5
Lecture:	1 x 1 Hours Weekly
Laboratory:	1 x 1 Hours Weekly
Prerequisite(s):	11679 (v.3) Pharmaceutical Biology 231 or any previous version
Principles of drug distribution and elimination. Parameters of clearance and volume of distribution, elimination rate constant and half life. Passage of drugs across biological membranes, relevance to absorption. Drug protein binding - consequences for distribution and clearance. Biochemistry and kinetics of drug metabolism. Induction and inhibition of metabolism. Renal drug processes. Concepts of steady state and average plasma drug concentrations in relation to drug administration.