8472 (v.11) Physiology 231

Area:

School of Biomedical Science

Credits:

25.0

Contact Hours:

5.0

Lecture:

3 x 1 Hours Weekly

Laboratory:

1 x 2 Hours Weekly

Equivalent(s):

301425 (v.4) BIO20 Physiological Concepts or any previous version
302420 (v.2) Physiological Concepts 205 or any previous version

Prerequisite(s):

    1644 (v.7) Human Biology 134 or any previous version
    OR
    302415 (v.2) Structure and Function of the Body 107 or any previous version
    OR
    6934 (v.4) Human Biology 136 or any previous version
    OR
    12931 (v.2) Pharmaceutical Biology 120 or any previous version

Syllabus:

Cellular physiology - cell membrane structure and composition. Active and passive mechanisms of membrane transport. Membrane potential. Movement of water and solutes across epithelia. Mechanisms of absorption (small intestine, kidney and gallbladder), mechanisms of secretion (salivary, pancreatic and stomach glands, kidney), Cellular metabolism, ATP and cellular energy transfer. Glycolysis and Krebs cycle. ETS. Oxidative Phosphorylation. Nerve/muscle - action potentials. Neuromuscular potentials. Neuromuscular transmission. Pacemaker cells. Electrophysiology of the heart. ANS function. skeletal, cardiac and smooth muscle. Cell communication. Chemical signalling. Receptors and signal transduction. Intracellular messengers. Homeostasis. Principles of endocrinology. Hypothalamic-pituitary interactions. TSH and thyroid hormone. ACTH and adrenal hormone. LH and FSH regulation of reproduction. Gastro-intestinal hormones. Energy metabolism - Fuel homeostasis and metabolic rate. Total body energy balance. Endocrine control during absorptive and post-absorptive states. Temperature regulation.

Unit Outcomes:

On successful completion of this unit students will have - Defined membrane potential and explain how it is maintained in resting and excitable cells. Discussed the mechanisms by which cells and tissues transport water and solutes. Demonstrated a workingknowledge of energy transfer mechanisms operating at both the cellular and tissue level of organization. Discussed the alteration of membrane potential as occurs with muscle contraction, neuronal signaling and synaptic transmission. Compared and contrasted structure and function in skeletal, smooth and cardiac muscle. Demonstrated a working knowledge of the gastro-intestinal system with respect to motility, secretion, digestion and absorption. Described the processes of secretion and absorption in the small intestine. Described the two major mechanisms by which hormones bring about their effects on their target tissues and explain how hormone release is regulated. Interpreted and explained the neural and hormonal relationship between the hypothalamus and the pituitary gland. Described the role of the trophic hormones and the effects of the hormones they regulate. Discussed the role of pancreatic hormones in intermediary metabolism.

Texts and references listed below are for your information only and current as of September 30, 2003. Some units taught offshore are modified at selected locations. Please check with the unit coordinator for up-to-date information and approved offshore variations to unit information before finalising study and textbook purchases.

Unit References:

Alberts B.E., et al, (1994), Molecular Biology of the Cell, 3rd ed, New York, Garland. Berne R.M. and Levy M.N., (1998), Physiology, 4th ed., St Louis, CV Mosby and Company. Ganong W.F., (1997), Review of Medical Physiology, 18th ed., Stamford, Appleton and Lange. Guyton A.C. and Hall J.E., (2000), Textbook of Medical Physiology, 10th ed., Philadelphia,WB Saunders Co. Jennett S., (1989), Human Physiology, Melbourne, Churchill Livingstone. Johnson L.R., (1998), Essential Medical Physiology, 2nd ed., Philadelphia, Lippincott-Raven Press. Martini F.H., (2001), Fundamentals of Anatomy and Physiology, 5th ed., Upper Saddle River,Prentice Hall. Martonosi A.N., (1982), Membranes and Transport, NY, Plenum Press. Mathews C.K. and van Holde K.E., (1996) Biochemistry, 2nd ed., California, Benjamin/Cummings Publishing Company. Patton H.D., et al, (1989), Textbook of Physiology - Volumes 1 and 2, Sydney, WB Saunders. Rhoades R. and Pflanzer R., (2003), Human Physiology, 4th ed., California, Thomson Learning.

Unit Texts:

Silverthorn D.U., (2001), Human Physiology - An Integrated Approach, 2nd ed., Upper Saddle River, Prentice Hall.

Unit Assessment Breakdown:

Assignment 10%. Practical Reports 25%. Theory Test 15%. Written Examination 50%. This is by grade/mark assessment.

Field of Education:

60100 Medical Studies (Narrow Grouping)

HECS Band (if applicable):

Extent to which this unit or thesis utilises online information:

Informational

Result Type:

Grade/Mark

Availability

Year	Location	Period	Internal	Area External	Central External
2004	Bentley Campus	Semester 1	Y

Area External	refers to external course/units run by the School or Department, offered online or through Web CT, or offered by research.
Central External	refers to external course/units run through the Curtin Bentley-based Distance Education Area

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