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302291 (v.3) ChE 379 Special Topics (Biochemical Engineering)
Area: | Department of Chemical Engineering |
Credits: | 12.5 |
Contact Hours: | 4.0 |
Lecture: | 1 x 2 Hours Weekly |
Tutorial: | 2 x 2 Hours Fortnightly |
Anti Requisite(s): | 304768 (v.2) ChE 579 Special Topics or any previous version
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Prerequisite(s): | 302240 (v.3) ChE 227 Process Principles or any previous version
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302252 (v.3) ChE 213 Process Engineering Materials - Make active for 2005 -remove discontinuation date or any previous version
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302253 (v.3) ChE 327 Process Heat Transfer or any previous version
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Syllabus: | Introduction to biology and microbiology (cell structure and micro-organisms). Cell chemistry, amino acids, carbohydrates, fats and lipids, protein structure and functions. Molecular biology, role and structure of RNA and DNA, mutation and genetic engineering. Energetics and metabolism (mechanisms and mathematical modelling).Enzymes and their catalytic activity, kinetic of a single substrate reaction. Enzyme inhibition, denaturation and inactivation. Methods of cell immobilisation. External and internal mass transfer limitations in bioprocesses. Stoichiometry of microbial growth. Unstructured models of microbial growth. Structured models of microbial growth. CSTR for bioprocesses. Week 10 - Enzyme catalysis in a CSTR. Chemostats in series. Plug flow and packed bed bioreactors. Gas-liquid mass transfer in bioreactors. Mass balance for two-phase bioreactors. Evaluation of mass transfer coefficient kLa and power requirements in bioreactors. |
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Unit Outcomes: | On successful completion of this unit students will have gained familiarity with the basic concepts of biochemical engineering, with one third of the course material devoted to the fundamental concepts of biology (cell and molecular biology, genetic engineering, and metabolism), one third devoted to enzyme kinetics relevant to biochemical processes and one third dedicated to the design of biochemical reactors. |
Texts and references listed below are for your information only and current as of September 30, 2003. Some units taught offshore are modified at selected locations. Please check with the unit coordinator for up-to-date information and approved offshore variations to unit information before finalising study and textbook purchases. |
Unit References: | Shuler, M. L. and Kargi, F., 2002, Bioprocess Engineering: Basic Concepts, Prentice Hall Inc., New York (2002). Raven, P. H. and Johnson, J. B., 1992, Biology, Third Edition, Mosby Year Book, St. Louis. Yin, J., 1999, 'Bio-informatics - A Chemical Engineering Frontier?' Chemical Engineering Progress, November: pp. 65,74. Bailey, J. E., 1998, 'Mathematical Modelling and Analysis in Biochemical Engineering: Past Accomplishments and Future Opportunities'. Biotechnology Progress, 14,20. Schilling, C. H. etal., 1999, 'Metabolic Pathway Analysis- Basic Concepts and Scientific Applications in the Post-genomic Era' Biotechnology Progress, 15,296, 303. |
Unit Texts: | Blanch, H. W. and Clark D. S., 1996, 'Biochemical Engineering', Marcel Dekker Inc. New York. |
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Unit Assessment Breakdown: | Assignments 20%. Quiz 20%. Final examination 60%. This is by grade/ mark assessment. |
Field of Education: | 30301 Chemical Engineering | HECS Band (if applicable): | 2 |
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Extent to which this unit or thesis utilises online information: | Informational | Result Type: | Grade/Mark |
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Availability
| Year | Location | Period | Internal | Area External | Central External | | 2004 | Bentley Campus | Semester 1 | Y | | |
Area
External | refers to external course/units run by the School or Department, offered online or through Web CT, or offered by research. |
Central
External | refers to external course/units run through the Curtin Bentley-based Distance Education Area |
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