8846 (v.7) Physiology 232

Area:

School of Biomedical Science

Credits:

25.0

Contact Hours:

5.0

Lecture:

3 x 1 Hours Weekly

Laboratory:

1 x 2 Hours Weekly

Equivalent(s):

302503 (v.2) Integrative Physiology 206
304590 (v.1) BIO28 Integrative Physiology or any previous version

Prerequisite(s):

    1644 (v.7) Human Biology 134 or any previous version
    OR
    302415 (v.2) Structure and Function of the Body 107 or any previous version
    OR
    6934 (v.4) Human Biology 136 or any previous version
    OR
    12931 (v.2) Pharmaceutical Biology 120 or any previous version

Syllabus:

Cardiovascular physiology - blood, haemostasis, electrical activity of the heart, control of heart rate and stroke volume, intrinsic and extrinsic regulation of blood flow/pressure, dynamics of blood flow, capillary exchange, circulatory patterns and control of blood pressure. Respiratory physiology - respiratory mechanics, gas transport and release, chemoreceptors and respiratory control, acid-base balance, hypoxia and anoxia, hyper and hypocapnia. Renal physiology - GFR, tubular function and plasma clearance, renal circulation, countercurrent mechanisms, diuresis and diuretics. Fluid and electrolyte balance - sodium, potassium, calcium, magnesium and acid-base balance, body fluid compartments.

Unit Outcomes:

On successful completion of this unit students will have - Described the composition, physical characteristics and general functions of blood. Described the process of blood clotting, noting the differences between the intrinsic and extrinsic pathways. Identified the major factors that determine cardiac output. Compared and contrasted the mechanisms by which blood pressure and blood flow are maintained at the systemic and tissue level. Explained the value and function of the capillaries and described the different mechanisms by which materials cross the capillary wall. Explained how the intrapulmonary and intrapleural pressures vary during ventilation and contribute to the proper functioning of the lung. Discussed the significance of surface tension in lung mechanics. Explained how the law of LaPlace applies to lung function and described the role of pulmonary surfactant as an 'energy-saving' substance in the lungs. Described those factors that shift the oxyhaemoglobin dissociation curve to the right. Explained the Bohr Effect in tissues and Haldane Effect at the lungs. Explained how, by monitoring the pH of CSF, the central chemoreceptors serve to regulate the arterial PCO2.

Text and references listed above are for your information only and current as of September 30, 2003. Please check with the unit coordinator for up-to-date information.

Unit References:

Berne R.M. and Levy M.N., (1998), Physiology, 4th ed., St Louis, CV Mosby and Company. Ganong W.F., (1997), Review of Medical Physiology, 18th ed., Stamford, Appleton and Lange. Guyton A.C. and Hall J.E., (2000), Textbook of Medical Physiology, 10th ed., Philadelphia,WB Saunders Co. Jennett S., (1989), Human Physiology, Melbourne, Churchill Livingstone. Johnson L.R., (1998), Essential Medical Physiology, 2nd ed., Philadelphia, Lippincott-Raven Press. Martini F.H., (2001), Fundamentals of Anatomy and Physiology, 5th ed., Upper Saddle River,Prentice Hall. Martonosi A.N., (1982), Membranes and Transport, NY, Plenum Press. Mathews C.K. and van Holde K.E., (1996) Biochemistry, 2nd ed., California, Benjamin/Cummings Publishing Company. Patton H.D., et al, (1989), Textbook of Physiology - Volumes 1 and 2, Sydney, WB Saunders. Rhoades R. and Pflanzer R., (2003), Human Physiology, 4th ed., California, Thomson Learning. SchmidtR.F and Thewes G., (1989), Human Physiology, 2nd ed., Berlin, Springer-Verlag.

Unit Texts:

Silverthorn D.U., (2001), Human Physiology - An Integrated Approach, 2nd ed., Upper Saddle River, Prentice Hall.

Unit Assessment Breakdown:

Assignment 10%. Practical Reports 25%. Theory Test 15%. Written Examination 50%. This is by grade/mark assessment.

Year	Location	Period	Internal	Area External	Central External
2004	Bentley Campus	Semester 2	Y	Y