301254 (v.2) Molecular Structure and Visualisation 333

Area:

School of Biomedical Science

Credits:

25.0

Contact Hours:

8.0

Lecture:

1 x 3 Hours Weekly

Individual Study:

1 x 5 Hours Weekly

Other Requisite(s):

Admission: dependent upon completion of Diploma of Technology, or equivalent at a Singapore Polytechnic.

Syllabus:

Purification of molecules, elucidating the 3D structure of molecules, amino and nucleic acid, molecular forces, peptide bonds, protein secondary structrue, protein tertiary structure, graphic visualisation of molecules, protein and nucleic acid folding.

Unit Outcomes:

On successful completion of this unit students will have - A theoretical understanding of how to purify proteins to homogeneity. An awareness of the principle methodologies used in the 3D structural determination of macromolecules. An understanding of the principles of protein structure and their interactions and be able to describe the nature of molecular forces involved. An understanding of the key issues relating to the flexibility and folding of macromolecules and the prediction of their structure. Developed the skills to search, retrieve, and interpret data files (pdb) describing macromolecular structure from the data banks. Theoretical understanding of molecular forces involved in protein structure and in modelling protein structure and other macromolecules. Developed the practical skills, and knowledge, to use molecular visualisation programs to view and manipulate macromolecules to highlight their atomic detail and interactions. Demonstrated written communication skills through practical and written assignments or assessments.

Text and references listed above are for your information only and current as of September 30, 2003. Please check with the unit coordinator for up-to-date information.

Unit References:

Updated references supplied with unit outline as they change frequently.

Unit Texts:

Branden, C. and Tooze, J., (1999) Introduction to Protein Structure, NY, Garland Publishing Inc.

Unit Assessment Breakdown:

Practical Assignment 50%. End of Semester Theory Examination 50%. This is by grade/mark assessment.

Year	Location	Period	Internal	Area External	Central External
2004	BPI Intern'l Group S'pore	Trimester 1	Y